Osteoarthritis in Veterinary Medicine

Sodium pentosan polysulphate is marketed and distributed worldwide in vertrinary medicine under the trade name Cartrophen Vet© by ARTHROPHARM. The therapeutic activity of the product arises from the action of sodium pentosan polysulphate on the underlying pathological processes of osteoarthritis and results in analgesic and regenerative effects. Cartrophen Vet© is indicated for the treatment of lameness and the pain of osteoarthritis (non-infectious arthrosis) and related musculoskeletal disorders in dogs.

Cartrophen Vet© possesses disease modifying and anti-arthritic chondroprotective properties. The pentosan polysulfate sodium in Cartrophen Vet© has been shown to:

• Stimulate chondrocytes which synthesize the cartilage matrix;
• Stimulate synoviocyte biosynthesis of hyaluronic acid;
• Inhibit and modulate pro-inflammatory mediators which are implicated in the degradation of cartilage matrix components;
• Mobilize thrombi and fibrin deposits in synovial tissues and subchondral blood vessels;
• Mobilize lipids and cholesterol in synovial and subchondral blood vessels;

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